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Nitric Oxide Donor Prevents Neonatal Isoflurane-induced Impairments in Synaptic Plasticity and Memory

Editor’s Perspective What We Already Know about This Topic Some general anesthetics have been shown to have adverse effects on neuronal development that affect neural function and cognitive behavior.Clinically relevant concentrations of inhalational anesthetics inhibit the postsynaptic density (PSD)-95, discs large homolog, and zona occludens-1 (PDZ) domain–mediated protein–protein interaction between PSD-95 or […]

By |February 1st, 2019|Uncategorized|0 Comments

Amisulpride for the Rescue Treatment of Postoperative Nausea or Vomiting in Patients Failing Prophylaxis A Randomized, Placebo-controlled Phase III Trial

Editor’s Perspective What We Already Know about This Topic Although antiemetics are commonly used to prevent postoperative nausea or vomiting, the failure rate is appreciable and there is little evidence to guide best therapy for rescue treatment after failed prophylaxis What This Article Tells Us That Is New Ten milligrams […]

By |February 1st, 2019|Uncategorized|0 Comments

Heterogeneity in Intensive Care Low Severity Does Not Mean Low Risk!

“…ild for a medical condition severe enough to require intensive care unit admission may already signify severe in terms of outcome…”
Source: Anesthesiology

By |February 1st, 2019|Uncategorized|0 Comments

Influence of Sex and Body Language on Patient Perceptions of Anesthesiologists

Editor’s Perspective What We Know about This Topic Patient perception of physician competence may depend on physician sex and body language What This Article Tells Us That Is New Actor anesthesiologists who maintained confident, high-power poses were considered smarter, more competent, more likely to be seen as leaders, and preferred […]

By |February 1st, 2019|Uncategorized|0 Comments

Cyclosporine before Coronary Artery Bypass Grafting Does Not Prevent Postoperative Decreases in Renal Function: A Randomized Clinical Trial: Erratum

In the article “Cyclosporine before Coronary Artery Bypass Grafting Does Not Prevent Postoperative Decreases in Renal Function: A Randomized Clinical Trial” (Ederoth P, Dardashti A, Grins E, Brondén B, Metzsch C, Erdling A, Nozohoor S, Mokhtari A, Hansson MJ, Elmér E, Algotsson L, Jovinge S, Bjursten H: Anesthesiology 2018; 128:710–7), there is an error in […]

By |February 1st, 2019|Uncategorized|0 Comments

Cognitive Effects of Perioperative Pregabalin Secondary Exploratory Analysis of a Randomized Placebo-controlled Study

EDITOR’S PERSPECTIVE What We Already Know about This Topic Perioperative administration of pregabalin has been associated with decreased postoperative pain and opioid requirements What This Article Tells Us That Is New This secondary analysis of data demonstrating that perioperative administration of pregabalin was associated with a reduction in opioid requirements […]

By |January 1st, 2019|Uncategorized|0 Comments

Blood Pressure and End-tidal Carbon Dioxide Ranges during Aneurysm Occlusion and Neurologic Outcome after an Aneurysmal Subarachnoid Hemorrhage

EDITOR’S PERSPECTIVE What We Already Know about This Topic It remains unknown what end-tidal carbon dioxide and mean arterial pressure are optimal for surgical management of patients with an aneurysmal subarachnoid hemorrhage What This Article Tells Us That Is New The investigators retrospectively evaluated 1,099 patients who had endovascular coiling […]

By |January 1st, 2019|Uncategorized|0 Comments

Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy A Systematic Review and Meta-analysis

EDITOR’S PERSPECTIVE What We Already Know about This Topic The incidence of major adverse cardiac events after electroconvulsive therapy is not known What This Article Tells Us That Is New Major adverse cardiac events and death after electroconvulsive therapy are infrequent and occur in about 1 of 50 patients and […]

By |January 1st, 2019|Uncategorized|0 Comments

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment Database Analyses and Systematic Review

EDITOR’S PERSPECTIVE What We Already Know about This Topic Dantrolene effectively treats malignant hyperthermia, but there are discrepant recommendations for dantrolene availability in facilities that stock succinylcholine for airway rescue but do not use volatile anesthetics. What This Article Tells Us That Is New The authors performed an analysis of […]

By |January 1st, 2019|Uncategorized|0 Comments

Analgesic Effects of Hydromorphone versus Buprenorphine in Buprenorphine-maintained Individuals

EDITOR’S PERSPECTIVE What We Already Know about This Topic The prevalence of patients prescribed buprenorphine for treatment of opioid use disorder is increasing Managing acute pain in buprenorphine-maintained individuals can be challenging What This Article Tells Us That Is New Large doses of intravenous hydromorphone can provide analgesia in buprenorphine-maintained […]

By |January 1st, 2019|Uncategorized|0 Comments